Due to its geographical location and cultural, political, social, etc. conditions, Iran has always been prone to various crises. For this purpose, the Ministry of Health has developed a program entitled "Health System Response to Disasters" for crisis management in the health system and communicated it to the universities of medical sciences. Considering the history of implementation of this program in the Qom Provincial Health Center, it seems that it has not been able to fully meet the needs of crisis management and, consequently, passive defense in this area. The aim of this research is to identify the challenges of implementing this program in the Qom Provincial Health Center and provide solutions to overcome these conditions. This research uses a qualitative descriptive-analytical method and, citing research literature, organizational information, and expert interviews, has extracted the program's challenges based on 12 criteria of the Burke-Litwin model. 45 important challenges have been extracted based on categorization, with 4 main categories and 12 subcategories. By providing exit strategies and solutions, it is expected that the following results will be achieved: implementation, promotion, effectiveness, efficiency and productivity of the program, response to the crisis, recording accurate information, staff performance, community behavior, crisis management, public participation, and program monitoring. The achievements of this research in the field of crisis management and passive defense are effective improvement of the health care system, promotion of the components of the health care system with respect to disasters, and reduction of the risks and consequences of disasters at the community level. Finally, the results of these steps have been summarized in a model.